A Novel Topical Spray which Efficiently Provides Relief for Patients Suffering from Pruritus
« Background: Pruritus is defined as an “unpleasant sensation that elicits the desire or reflex to scratch”. It can occur without injury or disease, serves no apparent biological purpose and has no recognizable endpoint. It appears along with a number of skin and systemic diseases. Aim: to determine the benefit of a novel topical anti-pruritic spray […]
Age-dependent transformation of skin biomechanical properties and micromorphology during infancy and childhood
Diaper dermatitis management: A global and innovative strategy for a new generation of skin care.
« Diaper rash affects up to 35% of infants with a peak around 10–12 months. Our research program on infant skin, focused on the epidermis, provided some evidences: barrier function is developing, inflammation signals are present and cellular resource needs to be preserved. The main causes of diaper rash are: altered barrier function and inflammation. We […]
A skincare combined with fixed adapalene and benzoyl peroxide combination provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne
« INTRODUCTION: Acne in adult women is an increasing reason for dermatological consultations. OBJECTIVE: The aim of this study was to assess in adult women with mild acne the efficacy and tolerance of a daily adjunctive application of a skincare (Normaderm® , Laboratoires Vichy, France) to a fixed combination of adapalene/benzoyl peroxide daily or every other […]
Modulation of hyperseborrhea by targeting inflammatory pathways involved in acne pathogenesis: in vitro and in vivo studies
« Introduction Acne is a chronic disorder of the pilosebaceous unit in which inflammation plays a central role. Indeed, inflammation represents an early event, and may be further amplified by both sebum lipid alteration and Propionibacterium acnes (P. acnes) proliferation. Sebum is not only produced in excess in acne (hyper-seborrhea), but its composition is also altered […]
Natural modulation of PAR-2 and TLR2: Application to clinical acne skin care
Inflammation plays a central role in acne. A global acne skin care product has been formulated with active principles: quinoa peptides (natural PAR-2 modulator), 5-alfa avocuta, zinc gluconate, capryloyl glycine, and long lasting alfa hydroxy acid derived. In vitro studies on 5-alfa avocuta in dermal fibroblasts significantly inhibited type 1 5-alfa reductase activity (-49%). In […]
Effect of a nutritional supplement in combination with topical Benzoyl Peroxide (BPO) in the management of mild to moderate acne
Evaluation of a non occlusive polymers ointment in a series of 71 cases of irritant contact dermatitis in building workers
Introduction Skin barrier rupture is one of the main physiopathology elements in irritant contact dermatitis. Its treatment involves – beside specific etiological and drug treatment – the use of topical insulating creams with specific composition in order to restore and protect the damaged skin. Objectives To assess the efficacy and tolerance of an ointment (BARIEDERM […]