Natural modulation of PAR-2 and TLR2: Application to clinical acne skin care

25 novembre 2021

Inflammation plays a central role in acne. A global acne skin care product has been formulated with active principles: quinoa peptides (natural PAR-2 modulator), 5-alfa avocuta, zinc gluconate, capryloyl glycine, and long lasting alfa hydroxy acid derived. In vitro studies on 5-alfa avocuta in dermal fibroblasts significantly inhibited type 1 5-alfa reductase activity (-49%). In […]

Modulation of hyperseborrhea by targeting inflammatory pathways involved in acne pathogenesis: in vitro and in vivo studies

25 novembre 2021

« Introduction Acne is a chronic disorder of the pilosebaceous unit in which inflammation plays a central role. Indeed, inflammation represents an early event, and may be further amplified by both sebum lipid alteration and Propionibacterium acnes (P. acnes) proliferation. Sebum is not only produced in excess in acne (hyper-seborrhea), but its composition is also altered […]

A skincare combined with fixed adapalene and benzoyl peroxide combination provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne

25 novembre 2021

« INTRODUCTION: Acne in adult women is an increasing reason for dermatological consultations. OBJECTIVE: The aim of this study was to assess in adult women with mild acne the efficacy and tolerance of a daily adjunctive application of a skincare (Normaderm® , Laboratoires Vichy, France) to a fixed combination of adapalene/benzoyl peroxide daily or every other […]