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Natural peroxisome proliferator-activated receptor-alpha agonist cream demonstrates similar therapeutic response to topical steroids in atopic dermatitis

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25 novembre 2021|
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Background: Atopic dermatitis (AD) requires permanent skin care. Objective: A cream containing 2% SO (sunflower oleodistillate), with peroxisome proliferator-activated receptor-alpha (PPAR-α) agonist properties, has been compared to a topical steroid (hydrocortisone butyro-propionate 1 mg/g). Methods: An open, randomized study included two groups of 40 children (aged 3 months to 4 years). Group A applied the […]

2010

Authors

Clarence De Belilovsky 1, Elia Roo-Rodriguez 2, Caroline Baudouin 3, Franck Menu 3, Bernard Chadoutaud 4 & Philippe Msika 3

Affiliations

1 Department of Dermatology, Institut Alfred Fournier, Paris, France ; 2 Department of Dermatology, Hospital Sur, Alcorcon, Madrid, Spain ; 3 Laboratoires Expanscience, Innovation Research and Development Direction, Epernon, France ; 4 ClinReal Online, Toulouse, France

Background: Atopic dermatitis (AD) requires permanent skin care.

Objective: A cream containing 2% SO (sunflower oleodistillate), with peroxisome proliferator-activated receptor-alpha (PPAR-α) agonist properties, has been compared to a topical steroid (hydrocortisone butyro-propionate 1 mg/g).

Methods: An open, randomized study included two groups of 40 children (aged 3 months to 4 years). Group A applied the steroid and group B applied the 2% SO cream, twice a day. SCORAD (SCORing Atopic Dermatitis) was determined at D0, D7 and D21 and quality of life (QoL) at D0 and D21.

Results: SCORAD was similar at D0 (37.2 versus 36.9), D7 (18.9 versus 19.2) (-49% and -48%) and D21 (11 versus 9.4) (-70% and -75%) (p < 0.01 versus D0). The Infant Dermatitis Quality of Life and Dermatitis Family Impact Questionnaire improved similarly by 65%/67% in group A and 72%/75% in group B at D21 (p < 0.01 versus D0).

Conclusion: A 2% SO cream has demonstrated therapeutic properties, using clinical scores and QoL, comparable to those of a topical steroid.